Dobutamine was developed in the 1970s by Drs. The drug is also commonly used in the goodman and gilman manual of pharmacology and therapeutics pdf setting as a pharmacologic stress testing agent to identify coronary artery disease.
The most dangerous side effect of dobutamine is increased risk of arrhythmia, including fatal arrhythmias. Rang HP, Dale MM, Ritter JM, Flower RJ. Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation”. This page was last edited on 30 January 2018, at 09:00. Efficacy spectrum of receptor ligands. However, a drug can act as a full agonist in some tissues and as a partial agonist in other tissues, depending upon the relative numbers of receptors and differences in receptor coupling. An example is the cannabinoid inverse agonist rimonabant.
It might be argued that the endogenous agonist is simply a partial agonist in that tissue. A few of these have been described. Potency is the amount of agonist needed to elicit a desired response. In general, the narrower this margin, the more likely it is that the drug will produce unwanted effects. The therapeutic index emphasizes the importance of the margin of safety, as distinct from the potency, in determining the usefulness of a drug.